Among the 64 genes that interacted with 367 drugs of T2D, ABCC8, ACE, ACHE, ADRB1, ADRB3, BRAF, HTT, INSR, KCNJ11, PDE3A, and PPARG genes were downregulated by wide range of (9–43) FDA approved drugs for T2D. Here, HTT is linked to type 2 diabetes mellitus.