This glycoprotein has been investigated in several diseases such as Alzheimer’s disease, obesity, and infertility because it is produced in many tissues and secreted in the blood, cerebrospinal fluid, and semen; therefore, clusterin kidney-related investigations must be performed in the urine to avoid extra-renal influences [6,22,23]. The gene discussed is CLU; the disease is early-onset autosomal dominant Alzheimer disease.