Changes in blood glucose levels in fasting-mimicking diets profoundly affect peripheral blood cell composition by reducing immunosuppressive myeloid and regulatory T-cell compartments.31 Patients with obesity with elevated blood glucose levels may have more immunosuppressive immune cells upon which anti-PD1/PD-L1 therapies can act. This evidence concerns the gene CD274 and obesity due to melanocortin 4 receptor deficiency.