The top 4 were “Cell matrix adhesion and organization” (COL6A1, COL6A2, COL18A1, JAM2, ADAMTS5 and POFUT2), “Immune/virus infection response” (MX1 and MX2), “Histone modification and chromatin remodeling” (NRIP1) and “Glycerolipid and lipid metabolism” (AGPAT3) (Figure 4). The gene discussed is ADAMTS5; the disease is viral infectious disease.