Next, ox-LDL-induced HUVECs were treated with GKT137831; Nox4 inhibitor, 4-PBA; ER stress inhibitor, N-acetylcysteine; ROS scavenger, and AICAR; AMPK activator to show the involved mechanism of AGE and decursin against endothelial dysfunction. Here, NOX4 is linked to endothelial dysfunction.