CRY2 and major depressive disorder: CRY2, a clock gene involved in orchestrating circadian rhythms (Sjoholm et al., 2010), was found to be downregulated in all tissues, but the prefrontal cortex was also identified as a hub in the short-term CR regulatory network, relating this gene to obesity and the nervous system, with four mined sentences identified linking this gene with depression—a high confidence result.