CRY2, a clock gene involved in orchestrating circadian rhythms (Sjoholm et al., 2010), was found to be downregulated in all tissues, but the prefrontal cortex was also identified as a hub in the short-term CR regulatory network, relating this gene to obesity and the nervous system, with four mined sentences identified linking this gene with depression—a high confidence result. This evidence concerns the gene CLOCK and major depressive disorder.