Phellodendron chinense C.K.Schneid., a frequently employed herbal remedy for treating gout or hyperuricemia, effectively restores the over-expression of IL-6 and p-c-Jun proteins, along with mRNA levels of AKT, MAPK3, MAPK8, and TP53 within the renal tissues of hyperuricemia-afflicted mice. This evidence concerns the gene MAPK8 and gout.