TNF and congenital rubella syndrome: Though the organ coefficient of the secondary immune organ, spleen, did not show a significant difference between the groups (p > 0.05, Figure 10J), we found that CRS significantly increased the levels of pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α, in the blood (all, p < 0.01) and brains (all, p < 0.001) of mice, and the positive drug imipramine can significantly reverse the surge of these cytokines in blood and brains (Figures 8A–F).