Our previous study also found that Zuotai reversed the reduced 5-HT level in the brain cortex of CUMS model mice (Zhao et al., 2018), and β-HgS enhanced the brain cortex 5-HT increase induced by antidepressant (sertraline) in the CRS + CUMS model mice (Qiao et al., 2022). Here, HGS is linked to congenital rubella syndrome.