It was found that compared with the control group, the number of Ki67 positive cells in the dentate gyrus of CRS + Vehicle group mice was significantly reduced (p < 0.05), while other groups (three Zuotai-treated groups, CRS+β-HgS group and CRS + IMI group) did not show a significant increase (p < 0.05). Here, MKI67 is linked to congenital rubella syndrome.