Then, compared with the CRS + Vehicle group, CRS + IMI group had a significant increase of Ki67 cells in the dentate gyrus (p < 0.05), and although the three Zuotai-treated groups (with order of CRS + Zuotai L group > CRS + Zuotai M group> CRS + Zuotai H group) and CRS+β-HgS group also increased the number of Ki67 positive cells in the dentate gyrus to a certain extent, there were no statistical difference (p > 0.05). The gene discussed is MKI67; the disease is congenital rubella syndrome.