MTDH and diabetic kidney disease: Liu et al., 2019 found that ACT001 ameliorates diabetic kidney disease by inhibiting the expression of MTDH, an oncogene, in a murine diabetes model. In another study, Zhong et al., 2018 revealed a therapeutic effect of ACT001 on hepatic steatosis in a murine diabetes model. Wu et al. found that ACT001 protected the intestine in an irradiation-induced intestinal injury model (Wu et al., 2022).