JAK/STAT activation or regulation by lncRNAs has been unveiled in CRC (ITIH4-AS1), chronic myeloid leukemia (MEG3) (Li et al., 2018), gastric cancer (LINC00691), osteosarcoma (lncRNA 135528), and non-small-cell lung cancer cells (PART1). Here, ITIH4 is linked to colorectal carcinoma.