In protumor conditions, Th2, Tregs, Th17, and myeloid-derived suppressor cells (MDSCs) secrete IL-1, IL-10, IL-17, and TGF-β through STAT3 and STAT5 signaling, which precludes immune function in the tumor microenvironment (TME) (Seif et al., 2017; Yoshimura et al., 2018; Kang et al., 2019). This evidence concerns the gene STAT3 and neoplasm.