Direct Calprotectin inhibition was however selected over a TLR4 blocking strategy, as diminished TLR4 activity has long been associated with impaired bacterial and viral infection clearance (O’Brien et al., 1980; Woods et al., 1988; Fukusaki et al., 2007; Khanolkar et al., 2009; Mansur et al., 2014). This evidence concerns the gene TLR4 and viral infectious disease.