Extracellular Calprotectin acts as a DAMP by engaging both TLR4 and RAGE (Schiopu and Cotoi, 2013) and also contribute to the response to infection via direct anti-microbial properties, notably, but not exclusively, due to its ability to withhold transition metals from pathogens (Sohnle et al., 2000; Besold et al., 2018). This evidence concerns the gene TLR4 and infection.