Mouse models of hyperlipidemia-induced full-blown atherosclerosis (e.g., ApoE-/- or LDLR-/- mice on a high-fat diet) were not used here, since, as opposed to the general population, atherosclerosis is often found without hyperlipidemia in late CKD patients (Massy and de Zeeuw, 2013; Ridker et al., 2017), in line with the lack of statin protection in this population. The gene discussed is APOE; the disease is hyperlipidemia.