Although the aging liver showed increased PCSK9 protein expression and a characteristic aging phenotype of the liver tissue with steatohepatitis, we did not investigate whether elevated PCSK9 contributed to the development of NASH-like features or the other way around, namely PCSK9 levels were increased due to inflammation and oxidative stress in the hepatic tissue. Here, PCSK9 is linked to metabolic dysfunction-associated steatohepatitis.