Long-term feeding of a high-fat diet deficient in choline has been found to promote the occurrence and development of nonalcoholic steatohepatitis (NASH) and NASH-related HCC by stimulating iNKT cell activation, CD8+ T cell infiltration in the liver, and upregulation of inflammatory cytokines (Figure 2; Sutti et al., 2014). The gene discussed is CD8A; the disease is metabolic dysfunction-associated steatohepatitis.