revealed that cancer-associated fibroblasts (CAF) deliver circ_0088300 to GC cells via exosomes, and that overexpression of exosomal circ_0088300 promotes upregulation of anti-apoptotic protein Bcl-2 expression and downregulation of apoptotic proteins Bax, caspase 3 and caspase 9 expression, thereby enhancing malignant cell transformation in vitro and promoting GC cell proliferation. Here, CASP9 is linked to gastric cancer.