circ-LDLRAD3 knockdown reduced drug resistance and inhibited the growth and invasion of CDDP-resistant GC cells, and mechanistically, knockdown of circ-LDLRAD3 inhibits CDDP chemoresistance and suppresses CDDP-resistant GC via miR-588 enrichment-mediated SOX5 (87). Here, SOX5 is linked to gastric cancer.