Besides, several genes are found to be hypermethylated in AD, including ANK1, RPL13, RHBDF2, DUSP22, SORL1, ABCA7, BIN1, SLC24A4, HLA-DRB5, HOXA, which are mainly related to Aβ deposition (Lunnon et al., 2014; Yu et al., 2015; Smith et al., 2018; Min et al., 2021; Nabais et al., 2021). Here, ANK1 is linked to Alzheimer disease.