Considering the important roles of tumor cells and the unique role of OG in the cell networks of the brain TME depicted by the single-cell datasets, the gene signatures of tumor components correlated with the recruitment of immune cells (named as “positive immune recruitment” (positive-IR) and “negative immune recruitment” (negative-IR) which were positively and negatively correlated with the expression level of CD45, respectively) and OG were also explored to create a holistic approach describing the TME of brain tumors. Here, PTPRC is linked to brain neoplasm.