Several recent proteomic and transcriptomic studies have demonstrated that MZB1 is highly expressed in the lymph nodes from patients with lupus or RA (9), fibrotic lung and skin (10), iris tissue and aqueous humor form patients with juvenile idiopathic arthritis-associated uveitis (11), and the gingiva of patients with chronic periodontitis (12–14), a major risk factor of RA. This evidence concerns the gene MZB1 and periodontitis.