In a similar in vitro experiment, pooled IgG from patients with AD could induce thymic invariant natural killer T cells (CD1d-restricted T cells that employ an invariant TCR alpha chain and a limited repertoire of beta chains) to produce higher levels of intracellular IL-4, IL-10, and IL-17 than did polyvalent IgG from healthy non-atopic individuals (100). This evidence concerns the gene IL4 and Alzheimer disease.