However, intramuscularly administered low doses of purified autologous total IgG (8 intramuscular injections of autologous total IgG 50 mg for 4 weeks) produced potent immunomodulatory effects (increased serum levels of IL-10 and IFN- γ) and long-term clinical improvement compared to intravenous administration of a high dose of heterologous IgG (1~2 g/Kg of body weight per a patient) in adolescent and adult patients with AD (66, 93). Here, IL10 is linked to Alzheimer disease.