MKI67 and neoplasm: In terms of the mechanism, HuoxueHuayu prescription was confirmed to refrain tumor cell proliferation [32, 44, 61, 62], adjust the equilibrium of MMP-2/TIMP-2 [44], abnormal miRNA expression such as miRNA-21, miRNA-143, miRNA-145, and miRNA-146a [61, 62], VEGF, and Ki-67 [32] to refrain tumor, and play a role in antitumor angiogenesis effect.