XBP1 and Hyperglycemia: The data showed high glucose and lipids mixture induced ER stress (PERK, CHOP, IREA, Xbp1, and ATF6), inflammation (iNOS and Cox2), and anti-angiogenic factors (Tbsp1) (Figure 2C), suggesting that in type 2 diabetes, hyperglycemia and hyperlipidemia contribute to the immune cells' dysregulation.