MME and hydrops fetalis: The PANORAMA-HF study (Prospective trial to assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 vs. ACEI for Medical treatment of Pediatric HF) is to determine if sacubitril/valsartan can offer a greater clinical treatment benefit compared to enalapril for pediatric HFrEF patients over 52 weeks treatment duration, as assessed using a global rank endpoint (7).