It is closely related to the occurrence and development of DKD, as it promotes the synthesis of ECM components such as collagen, fibronectin, laminin, and proteoglycan, inhibits the synthesis of enzymes that degrade ECM components, and induces its formation through autocrine action, significantly enhancing its biological activity, exerting its effect of promoting fibrosis, and ultimately causing renal interstitial fibrosis [34]. The gene discussed is LAMB2; the disease is fibrosis.