DM: Diabetes mellitus; DKD: Diabetic kidney disease; STZ: Streptozotocin; NNAV: Naja naja arta venom; Glu: Glucose; BUN: Blood Urea Nitrogen; SCr: Serum Creatinine; PRO-U: Urinary protein; MDA: Malondialdehyde; SOD: Superoxide Dismutase; TC: Total cholesterol; TG: Triglyceride; TGF-β1: Transformation Growth Factor-β1; α-SMA: α-smooth muscle actin; ECM: extracellular matrix protein; HK-2: human proximal tubular epithelial cells; MyoF: myofibroblast; TIF: tubulointerstitial fibrosis; TEMT: tubular Epithelial myofibroblast transdifferentiation; WB: western-blotting; CTX: cobra α-neurotoxin. The gene discussed is ACTA1; the disease is diabetes mellitus.