In humans, MYCN is located on chromosome 2p24.3, and its mutations (loss-of-function) are known to cause type I Feingold syndrome (FS1), which is characterized by variable combinations of microcephaly, limb malformation/digit anomalies, intestinal atresia (blockage/obstruction), and mild to moderate intellectual disability (Courtens et al., 1997; Celli et al., 2003; Bokhoven et al., 2005). Here, MYCN is linked to microcephaly.