LHX2 and autism spectrum disorder: However, LHX2 haploinsufficiency has now been linked to variable neurodevelopmental disorders (Schmid et al., 2023); the authors identified de novo deletions (likely gene-disrupting) and missense variants in LHX2 from 19 individuals (18 families) presenting with a variable neurodevelopmental phenotype, including microcephaly, intellectual disability, autism spectrum disorder, and other behavioral anomalies.