FOXR1 and microcephaly: Interestingly, some of the upregulated genes by FOXR1 overexpression are involved in ribosome biogenesis (e.g., ribosome biogenesis regulator 1 and RRS1), an essential driver in neurodevelopment, whose dysregulation is associated with microcephaly and other neurodevelopmental syndromes (Hetman and Slomnicki, 2019).