The results of multivariate logistic regression analysis showed that BISAP (OR = 6.187; 95% CI: 2.259–27.047; p = 0.003), PCT (OR = 1.923; 95% CI: 1.040–5.568; p = 0.124), and rad-score (OR = 3.841; 95% CI: 1.578–13.481; p = 0.013) were independent predictors of progression of acute pancreatitis, and two factors, MCTSI (OR = 1.281; 95% CI: 0.690–2.617; p = 0.455) and CRP (OR = 1.001; 95% CI: 0.992–1.010; p = 0.872), were not independent factors. Here, CRP is linked to acute pancreatitis.