The inductionof CD4+ T cell death through mitochondrial ROS productionby fatty acids has been observed, with subsequent research indicatingthat ROS knockout serves to limit CD4+ T cell loss andminimize tumor burden.159 It has been hypothesizedthat the impact of CD4+ T cells on tumor growth is primarilyattributed to their capacity to initiate immune responses that arespecific to the tumor. The gene discussed is CD4; the disease is neoplasm.