LTA hasthe potential to facilitate the development of HCC by augmenting thesenescent HSCs.144 Furthermore, LTA collaborateswith deoxycholic acid (DCA), a secondary bile acid that is generatedby the microbiota in the gastrointestinal tract, to govern theexpression of SASP factor and cyclooxygenase-2 (COX2) via theparticipation of TLR2.145 The onset ofobesity resulting from exposure to a high-fat diet (HFD) has beenfound to interfere with the functioning of the cytotoxic CD8+ T cells in the tumor microenvironment. Here, CD8A is linked to hepatocellular carcinoma.