Ithas been observed that individuals who have been exposed to both HBVand AFB1 are at the highest risk for developing HCC.135 Genetic anomalies in human cancers have been noted, specificallythe prevalence of somatic mutations in the p53 tumor suppressor gene.Numerous investigations have supported the high incidence of p53 mutationin HCC. This evidence concerns the gene TP53 and hepatocellular carcinoma.