A further intriguing aspect of the mode-of-action of FR has comefrom its application to GTPase-deficient Gαq andGα11 proteins bearing the Q209L/P mutations, whichis causative for a notable fraction of uveal melanoma cases in humans.21 GαqQ209L/P proteinsare constitutively bound to GTP and are therefore active irrespectiveof receptor input. The gene discussed is GNAQ; the disease is uveal melanoma.