IGHE and allergic disease: The positive IgE correlations of Ara h 9 peptides with known major allergen IgE epitopes and epitopes important in predicting desensitization (Ara h 1 peptide 116, Figure 4), along with these peptides experiencing a shift towards increased IgG4 binding, highlights that Ara h 9 may have greater roles in the development and treatment of allergy given that it is a major allergen in Mediterranean populations (18, 45, 46).