HSF4 and stroke disorder: As shown in Figure 7A–C, MCAO resulted in severe impairment of sensorimotor functions in the vehicle group, as evidenced by an increase in the time to touch and remove the adhesive tape from the forepaws, as well as the increase in the asymmetry rate in the cylinder test, whereas Tat‐SIRT5‐CTM treatment facilitated neurological recovery after stroke.