Although exact mechanisms are not completely elucidated, deletion of Ccl17 in mice seems to reduce myocardial fibrosis and improve cardiac function after myocardial infarction, infusion with angiotensin II or infusion with phenylephrine, possibly by reducing the influx of anti-inflammatory regulatory T cells (Tregs).80 The gene discussed is AGT; the disease is Myocardial fibrosis.