Its subunits were also found to be crucial for cancers, including FXYD3, FXYD4, FXYD5 etc.28, 29Due to FXYD6 is an unnecessary subunit of NKA, and could regulate its activity, therefore, we speculated that FXYD6 could change the cell status of GBM cell by regulating NKA. Here, FXYD4 is linked to cancer.