Taken together, there is a possbile role of FXYD6 in gliomas by interacting with and regulating TRPV1 channel, which needs to be further studied comprehensively, via overexpressing the FXYD6 and/or TRPV1 in GBM cell lines to confirm that whether FXYD6 could affect the cell status, including cell death, apoptosis, and so on. This evidence concerns the gene TRPV1 and central nervous system cancer.