Taken together, there is a possbile role of FXYD6 in gliomas by interacting with and regulating TRPV1 channel, which needs to be further studied comprehensively, via overexpressing the FXYD6 and/or TRPV1 in GBM cell lines to confirm that whether FXYD6 could affect the cell status, including cell death, apoptosis, and so on. Here, TRPV1 is linked to glioblastoma.