In the retrospective analysis of the metabolome profiling data from tumour tissues, levels of 2‐PG, phosphoenolpyruvate and pyruvate, which were downstream products of PGAM1, were observed to decrease in the RFX6‐KO group and increase in the RFX6‐OE group (Figure S5A,B). This evidence concerns the gene RFX6 and neoplasm.