IHC staining of tumour tissues from previous models also showed the decreased expression of PGAM1 in the RFX6‐KO cells and increased expression in the RFX6‐OE cells in vivo (Figures 2H and 3H), supporting the transcriptional regulation of PGAM1 by RFX6 in HCC cells. Here, RFX6 is linked to hepatocellular carcinoma.