Single-target IHC revealed that eight ApoER2-Dab1 pathway markers (Dab1, pP85αTyr607, pLIMK1Thr508, pTau, pPSD95Thr19, pDab1Tyr220, ApoE, ApoJ) accumulated within abnormal neurons or NPs, were higher in MCI and sAD cases than controls, and positively correlated with histological progression or cognitive deficits (Figs. 6, 7 and 8, Additional file 1: Ext Fig. S6.1). The gene discussed is LRP8; the disease is Cognitive impairment.