However, Reelin aggregates were less common and much less prominent in ProS-CA1 than we previously observed in the CA2 and CA3 regions of the hippocampus [131] (see Additional file 1: Ext Fig. S6.2) and thus did not correlate with histological progression or antemortem cognitive deficits (Fig. 6). This evidence concerns the gene RELN and Cognitive impairment.