The level of LC3-II increased and that of p62 decreased when only nutlin-3a was administered, but co-treatment with bafilomycin A1 and nutlin-3a resulted in the accumulation of both LC3-II and p62 in KRAS MT/p53 WT NSCLC cells (Fig. 2B). This evidence concerns the gene KRAS and non-small cell lung carcinoma.