TP53 and non-small cell lung carcinoma: In conclusion, nutlin-3a induced the downregulation of the KRAS/PI3K/mTOR pathway and methuosis-like cell death by disrupting the fusion of lysosomes with both macropinosomes and autophagosomes, which is reliant on the suppression of GFPT2 in the HBP of KRAS MT/p53 WT NSCLC cells (Fig. 8H).