Combining above results, GFPT2, glutamine-fructose-6-phosphate transaminase 2, which is linked to the HBP related metabolic pathway, was identified as significantly downregulated only in KRAS MT/p53 WT NSCLC cells and confirmed via RT-qPCR (Fig. 5A, Suppl. The gene discussed is TP53; the disease is non-small cell lung carcinoma.