5Given the strong connections between USP13 and MYC in human LUSC and KPU lung squamous tumors (Fig. 4) and the stabilization of MYC protein through the deubiquitinating activity of USP13 (Fig. 5), we examined the expression pattern of MYC during KP and KPU tumorigenesis following Ad5-SPC-Cre or Ad5-CC10-Cre infection. This evidence concerns the gene MYC and infection.