HAND2 and renal dysplasia: Additionally, several transcription factors involved in cardiovascular development and function were targeted by hypermethylated DMCs, such as HAND2, which plays a role in cardiac and aortic morphogenesis [55], GATA3, which is involved in endothelial cell biology and renal dysplasia when mutated [56], and T-Box transcription factors (TBX1, TBX2 and TBX5) and myosin-binding protein C (MYBPC3), which are involved in the development of the pharyngeal arch arteries [41], formation of the chambers of the myocardium and cardiomyocyte development [42].