For example, sEVs derived from Akkermansia muciniphila when intravenously injected into PCa mouse Xenograft mode, resulted in an increased proportion of CD8+ T cells for granzyme B (GZMB) and interferon-gamma (IFN-γ) lymphocytes, leading to an increased M1 macrophages and a decreased M2 macrophages. The gene discussed is IFNG; the disease is posterior cortical atrophy.