INS and obesity due to melanocortin 4 receptor deficiency: [33] constructed HUCMSCs stably overexpressing IL-10 which were applied to obese mice, and compared with HUCMSCs, IL-10-HUCMSCs treatment had much better anti-obesity effects, including body weight reduction, greater glucose tolerance, less systemic insulin resistance, and less adipose tissue inflammation in HFD feeding mice.