Thirty mRNAs involved in the regulation of Th2 function are shown in Fig. 7C. In addition to IL-10, EPHA2 and PTX3 were upregulated in IL-10-MSCs-CD4+ T cells, which have been reported to play an inhibitory role in Th2 function [23] or airway hyperresponsiveness [24]. Here, CD4 is linked to airway hyperresponsiveness.