Chronic in vivo treatment with A-804,598 in SOD1G93A mice was shown to inhibit the upregulation of SQSTM1/p62 in the lumbar medulla by inhibiting P2 × 7R, confirming that P2 × 7 is an in vivo regulator of autophagy in the pathogenesis of ALS [56]. The gene discussed is SQSTM1; the disease is amyotrophic lateral sclerosis.