Meanwhile, inhibiting miR-125b using LNA inhibitor in the miR-125b-high MDA-MB-231 and MDA-MB-415 breast cancer cells resulted in increased E2F3, CDK2, CCNA2 and Bak1 protein expression and increased phosphorylation of Rb, which is indicative of increased G1-S progression with miR-125b inhibition (Fig. S5C). The gene discussed is E2F3; the disease is breast cancer.