Exogenous factors are known to activate PI3K/AKT signaling [60] and we have previously shown that altruistic miR-125bHigh breast cancer cells secrete trophic factors such as CCL28 and IGFBP2 (Fig. 2G -I) – we thus hypothesized that exogenous CCL28 or IGFB2 may induce PI3K-AKT activation, thereby reducing miR-125b expression. This evidence concerns the gene IGFBP2 and breast cancer.