The authors also showed that OGT knockdown was associated with a decrease in H3K79me2 levels and the enrichment of HOXA9/MEIS1 mRNA (genes involved in the initiation and progression of the disease) and H3K79me2/DOT1L on the HOXA9/MEIS1 promoter, illustrating the role of DOT1L O-GlcNAcylation in MLL fusion leukemia pathogenesis [60]. This evidence concerns the gene DOT1L and leukemia.