It inhibits Wnt signaling and consequently the epithelial–mesenchymal transition (EMT) associated with tumor initiation, invasion, metastasis, and resistance to therapy [11]; CDX2 hypermethylation is frequent in late stages of lung cancer [12] and plays an important role in the activation of lung cancer cell proliferation by suppressing Wnt signaling [13]. The gene discussed is CDX2; the disease is lung carcinoma.