PCSK9 and lung adenocarcinoma: As showed in Fig. 12A, ACAP3, ATP8B3, and CDK5R1 were significantly upregulated in lung adenocarcinoma cells (A549/PC9), while the those of BTK, CAV2, GRIA1, PCSK9 and PLA2G3 were downregulated in A549/PC9 compared to the levels in BEAS-2B.