MYC and cancer: As presented from the GSVA enrichment analysis, the enrichment of high risk was found in cancer-associated pathways, cell cycle and metabolism, including angiogenesis, epithelial mesenchymal transition, mTOR signaling, myc-targets pathway, G2/M checkpoint, hypoxia, glycolysis, and reactive oxygen species pathway (Fig. 10A, Additional file 2: Figure S10A, B).