To assess the relative contribution of hematopoietic and nonhematopoietic cells to the sepsis exacerbation in IL-36R−/− mice, we used reciprocal bone marrow (BM) transplantation and generated the following chimeric mice: WT → WT, IL-36R−/− → WT, WT → IL-36R−/−, and IL-36R−/− → IL-36R−/− (Fig. 5A). The gene discussed is IL1RL2; the disease is Sepsis.