Third, in terms of applications, the tumor inhibition effect of siRNA-LNP alone is not obvious, there is a partial tumor inhibition effect with the combination of PD-L1 inhibitors and siRNA-LNP, but both targets are PD-L1, so the functionally limited drug efficacy is difficult to break through, so it also needs to be combined with other drugs or to humanize mouse experiments to further illustrate the drug efficacy of siRNA. Here, CD274 is linked to neoplasm.