During malaria infection by Plasmodium falciparum, PfEMP1 DBL (Duffy-binding like) domains on infected erythrocytes (IEs) can adhere to surface vascular receptor intercellular adhesion molecule-1 (ICAM-1), and this association is implicated in the pathogenesis of severe malaria including cerebral malaria. The gene discussed is ICAM1; the disease is malaria.