The extracellular domain of PfEMP1 mediates the adhesion with specific endothelial receptors ICAM-1, EPCR, CD36, and CSA and plays a prominent role in the pathogenesis of severe and cerebral malaria as this sequestration leads to circulatory disturbances and inflammation affecting one or more organs leading to severe disease and fatal complications [3–5]. Here, ICAM1 is linked to cerebral malaria.