Yang and coworkers [42] also reinforced the role of IL-6 and other cytokines like IL-1β and TNFα in disruption of blood–brain barrier (BBB), leading to neurological degeneration in such diseases as Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), and posttraumatic brain injury (TBI). The gene discussed is TNF; the disease is early-onset autosomal dominant Alzheimer disease.