IL6 and early-onset autosomal dominant Alzheimer disease: Yang and coworkers [42] also reinforced the role of IL-6 and other cytokines like IL-1β and TNFα in disruption of blood–brain barrier (BBB), leading to neurological degeneration in such diseases as Alzheimer’s disease (AD), stroke, multiple sclerosis (MS), and posttraumatic brain injury (TBI).