In uEVs from patients with autosomal dominant tubulointerstitial kidney disease associated with the MUC1 gene (ADTKD-MUC1), proteins that are functionally linked to vesicular transport and membrane dynamics, such as vacuolar protein sorting-associated protein (VTA1), were significantly reduced [51]. Here, VTA1 is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.