AKT1 and rheumatoid arthritis: Analysis revealed that 15 immunological pathways were upregulated in OBM cases: chemokine signaling pathway, viral Protein interaction with cytokine and cytokine receptor, cytokine-cytokine receptor infraction, IL-17 signaling pathway, human cytomegalovirus infection, rheumatoid arthritis, intestinal immune network for IgA production, focal adhesion, malaria, MAPK signaling pathway, Ras signaling pathway, pathway in Cancer, PI3k-Akt signaling pathway, calcium signaling pathway and Rap-1 signaling pathway (Fig. 3A–D).