Overall, these DEPs are involved in tissue remodeling in the setting of active chronic inflammation in OBM patients interacting to upregulate RANKL and TNF alpha signaling and targeting NF-κB, MAP Kinase and PPAR induced macrophage and neutrophil dependent tissue remodeling (Supplementary Figs. 2 and 4). The gene discussed is NFKB1; the disease is inflammation.