The enrichment of genes related to phagocytosis (e.g. PROS1, WASF2), lysosomal degradation, oxidative stress (e.g. CAT, CTSF) and proteasome function (PSMD5) in the consensus microglia may suggest responses to the pathological environment in the PD brain, and possible alterations in the microglial phagocytic and lysosomal machinery. The gene discussed is PSMD5; the disease is Parkinson disease.