Whereas we detected no significant differences in cytokine secretion in the isogenic pair of iMGL (Fig. 4f), LRRK2-G2019S-carrying m-PD iMGL showed higher secretion of pro-inflammatory IL8 and TNFα and anti-inflammatory IL10 in response to LPS + IFNγ stimulation (Fig. 4g), suggesting altered cytokine release in response to heavy inflammatory stimulation in male PD-iMGL. The gene discussed is CXCL8; the disease is Parkinson disease.