However, in the liver of the 129sve 5LO−/− mice, we were able to identify a decrease for these genes expression in the T1D group, but Cap treatment was capable to restore the expression of these genes (Insr: 5LO−/− + Cap vs 5LO−/− T1D p = 0.0448; 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0029; Irs1: 5LO−/− vs 5LO−/− T1D p = 0.0027; 5LO−/− + Cap vs 5LO−/− T1D + Cap p = 0.0396; 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0001; Ampk: 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0128) in the same way that we observed in the muscle of these mice (Fig. 7A–F). Here, IRS1 is linked to type 1 diabetes mellitus.