Adiponectin plasma levels were decreased on both 129sve 5LO−/− T1D treated or not with Cap (5LO−/− + Cap vs 5LO−/− T1D p = 0.0307; 5LO−/− + Cap vs 5LO−/− T1D + Cap p = 0.0045), but only in this genotype, indicating that LTs absence could be linked to the observed plasma decreased levels of this adipokine (Fig. 3I, J). This evidence concerns the gene ADIPOQ and type 1 diabetes mellitus.