SLC2A4 and type 1 diabetes mellitus: Following a similar pattern, we observed the same phenomenon related both glucose transporter 4 (Glut4) and adenosine monophosphate-activated protein kinase (Ampk), responsible for glucose uptake, fatty acid oxidation and energy homeostasis in muscles, but only in the muscles of 129sve 5LO−/− mice (Glut4: 5LO−/− vs 5LO−/− T1D p < 0.0001; 5LO−/− + Cap vs 5LO−/− T1D p < 0.0001; 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0002; Ampk: 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0219) (Fig. 6E–H).