Interestingly, we observed that leptin plasma concentration was reduced in 129sve T1D (Cap vs T1D p = 0.0458; Cap vs T1D + Cap p = 0.0403) and 129sve 5LO−/− T1D (5LO−/− + Cap vs 5LO−/− T1D p = 0.0010; 5LO−/− + Cap vs 5LO−/− T1D + Cap p = 0.0015) mice, regardless of Cap treatment or genotype (Fig. 3C, D). This evidence concerns the gene LEP and type 1 diabetes mellitus.