We have noticed that both Insr and Irs1 presented reduced expression in T1D mice muscle, regardless of the genotype, but Cap was able to increase the expression of these genes (Insr: Wt vs T1D + Cap p = 0.0106; T1D vs T1D + Cap p = 0.0388; 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0137; Irs1: T1D vs T1D + Cap p = 0.0376; 5LO−/− T1D vs 5LO−/− T1D + Cap p = 0.0294), in a more accentuated way in muscle from 129sve 5LO−/− mice (Fig. 6A–D). The gene discussed is IRS1; the disease is type 1 diabetes mellitus.