INS and type 1 diabetes mellitus: Regarding plasma insulinemia in these animals, we observed that, as expected, the insulin concentration in both groups (treated or not with Cap) of 129sve T1D and 129sve 5LO−/− T1D mice was lower when compared to their respective control or treated groups (Wt vs T1D ns p = 0,1654; Wt vs T1D + Cap ns p = 0.1788; Cap vs T1D p = 0.0216; Cap vs T1D + Cap p = 0.0251; 5LO−/− vs 5LO−/− + Cap p = 0.0071; 5LO−/− vs 5LO−/− T1D p < 0.0001; 5LO−/− vs 5LO−/− T1D + Cap p < 0.0001) (Fig. 2C, D).