AGT and type 1 diabetes mellitus: Interestingly, we have also observed a similar pattern in relation to gene expression of At1 (Wt vs T1D + Cap p = 0.0016; 5LO−/− vs 5LO−/− T1D + Cap p = 0.0064), the gene responsible for encoding the receptor that binds to angiotensin II (Fig. 4C, D).