Regarding the RAS pathway and its role in T1D metabolic impairments, we observed increased Agt expression, in both muscle and liver from T1D mice, and Cap treatment presented a main role over this effect, however, this increased expression seems to be independent of the presence of LTs, since the expression of this gene was similar for both 129sve and 129sve 5LO−/− mice. Here, AGT is linked to type 1 diabetes mellitus.